Astragali radix is a dried root of the genus astragalus or astragalus membranaceus. The "Shen Nong's Herbal Classic", which was published in the late Eastern Han Dynasty, indicates that it has a history of medicinal use for more than 2000 years. It is listed as the top grade in the "Compendium of Materia Medica", and it is believed that astragalus membranaceus has the function of benefiting qi and generating yang, inducing diuresis and relieving swelling, consolidating superficies for arresting sweating, and promoting pus discharge and tissue regeneration. The chemical constituents of astragalus include polysaccharide components such as dextran and heteropolysaccharides, various saponins such as baicalin I, II, III and soybean saponin, aspartic acid, serine and other amino acids, various trace elements, folic acid and linoleum acids, sterols, etc. At present, the research on the chemical constituents of astragalus membranaceus mostly focuses on astragalus polysaccharide, astragalus saponin or its effective monomer components. Modern pharmacological studies have shown that astragalus membranaceus has biological activities such as anti-tumor, immune regulation, cardiovascular protection, liver protection, improvement of nervous system function, and anti-osteoporosis. Among them, astragalus membranaceus has a certain regulatory effect on bone cell metabolism. Through the literature review of the effects of astragalus membranaceus on bone metabolism and related basic research in recent years, it is found that astragalus and other astragalus membranaceus extracts and astragalus preparations regulate bone metabolism by promoting osteoblasts and by inhibiting osteoclasts. It is regulated by promoting the secretion of osteoporin and the regulation of hormone levels. This paper reviews the research on the basics of bone metabolism, animal models, and clinical aspects of astragalus preparations, in order to provide some help for the study of the influence of Chinese medicine astragalus on bone cell metabolism and to provide ideas and reference for the prevention and treatment of osteoporosis. |