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| 血清维生素K1水平与绝经后女性腰椎骨密度相关性分析 |
| Analysis of serum vitamin K1 levels and bone mineral density in postmenopausal women |
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| DOI：10.3969/j.issn.1006-7108.2019.04.012 |
| 中文关键词: 维生素K1 骨密度 骨质疏松症 绝经后女性 腰椎 酶联免疫吸附试验 |
| 英文关键词:Vitamin K bone mineral density osteoporosis postmenopausal women lumber spine ELISA |
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| 中文摘要: |
| 目的 探讨绝经后女性骨密度与血清维生素K1水平之间的相关性。方法 使用标准化的酶联免疫吸附试验(ELISA)试剂盒测量46例绝经后骨质疏松女性和30名绝经后健康对照女性的血清维生素K1水平。检测腰椎(1~4)的骨密度(bone mineral density, BMD)。结果 绝经后骨质疏松女性组血清维生素K1水平明显低于正常对照组(P<0.05)，绝经后骨质疏松女性血清维生素K1浓度与腰椎BMD呈正相关(R = 0.545，P = 0.003)；绝经后正常对照组血清维生素K1浓度与腰椎BMD呈正相关(R = 0.513，P = 0.009)。维生素K1对骨质疏松症的诊断敏感性和特异性分别为91％和98％(截止值：0.853 ng/mL);维生素K1的ROC曲线下面积(AUC)为0.985，奇数比为18.88。结论 维生素K1与诊断绝经后骨质疏松症呈负相关。 |
| 英文摘要: |
| Objective To investigate the correlation between bone mineral density and serum vitamin K1 levels in postmenopausal women. Methods Serum levels of vitamin K1 were measured in 46 postmenopausal osteoporotic women, and in 30 postmenopausal healthy control women using a standardized Enzyme-Linked Immune Sorbent Assay (ELISA) kit. Bone mineral density (BMD) was assessed at the lumbar spine L1-4. Results The mean serum vitamin K1 level was significantly lower in the postmenopausal osteoporosis group than in the normal control group (P<0.05), and serum vitamin K1 concentration was positively correlated with lumbar spine BMD among postmenopausal osteoporotic women (R = 0.545，P = 0.003), and in postmenopausal healthy controls (R = 0.513，P = 0.009). Diagnostic sensitivity and specificity of vitamin K1 for osteoporosis were 91％ and 98％, respectively (cut-off value: 0.853 ng/mL). The area under the ROC curve (AUC) value for vitamin K1 was 0.985, and the odd ratio result was 18.88. Conclusion Our results suggest that vitamin K1 is negatively correlated with the diagnosis of postmenopausal osteoporosis. |
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