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| 白藜芦醇对绝经后骨质疏松女性骨代谢和氧化代谢产物水平的影响 |
| Effect of resveratrol on biomarkers of protein oxidation in postmenopausal women with osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2019.04.020 |
| 中文关键词: 氧化应激 骨质疏松症 骨代谢 白藜芦醇 绝经后妇女 |
| 英文关键词:oxidative stress osteoporosis bone metabolism resveratrol postmenopausal women |
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| 中文摘要: |
| 目的 探讨白藜芦醇对绝经后骨质疏松症妇女骨代谢和氧化代谢产物水平的影响。方法 选取 2015年11月至 2017年11月在成都市第二人民医院就诊的84例绝经后骨质疏松症患者作为研究对象，随机分为治疗组和对照组。治疗组的患者每天服用白藜芦醇，对照组的患者给予安慰剂片。3个月后，测量各组患者的血清骨代谢标志物[I型前胶原氨基端前肽(PINP)、骨钙素(BGP)、骨碱性磷酸酶(BALP)、I 型胶原 C 末端肽特殊序列(β-CTX)]和氧化代谢产物[蛋白羰基(PCO)、高级氧化蛋白产物(AOPP)、总抗氧化能力(TAC)、Akatsu(MDA)]水平的改变。结果 服用白藜芦醇治疗后，治疗组血清PINP 、BGP 、BALP 、β-CTX 、PCO、AOPP和MDA水平较治疗前显著降低(P＜0.05)，治疗后两组之间的差异具有统计学意义(P＜0.05)；治疗组血清TAC水平较治疗前显著升高(P＜0.05)，治疗后两组之间的差异具有统计学意义(P＜0.05)。然而，对照组治疗前后的PINP 、BGP 、BALP 、β-CTX 、PCO、TAC、AOPP和MDA指标，其差异并没有统计学意义(P＞0.05)。结论 白藜芦醇可以降低绝经后骨质疏松症女性体内氧化应激和高骨转化速度。 |
| 英文摘要: |
| Objective To investigate the effect of Resveratrol on protein biomarkers of postmenopausal women with osteoporosis. Methods Eighty-four postmenopausal osteoporosis patients treated in our hospital from November 2015 to November 2017 were selected as the study subjects; all patients were randomly divided into two groups: the resveratrol treatment group and the control group. The treatment group participants took resveratrol daily for 3 month and the control group participants took placebo tablets in the same way. After 3 months, serum bone metabolism markers type I procollagen amino terminal propeptide (PINP), osteocalcin (BGP), bone alkaline phosphatase (BALP), type I collagen C-terminal peptide specific sequence (β-CTX), plasma protein carbonyl (PCO), advanced oxidation protein product (AOPP), total antioxidant capacity (TAC), and Akatsu (MDA) levels were measured. Results After treatment with resveratrol, serum PINP, BGP, BALP,β-CTX , PCO, AOPP and MDA levels of this group were significantly lower than before treatment (P<0.05), and there was also a statistically significant difference between the two groups after treatment (P<0.05); resveratrol group Serum TAC levels were significantly higher than before treatment (P<0.05); in addition, there was a significant statistical difference between the two groups after treatment (P<0.05); however, No difference of the above indicators PINP, BGP, BALP,β-CTX PCO, TAC, AOPP and MDA were observed before and after treatment in the control group (P>0.05). Conclusion Resveratrol can reduce oxidative stress and high bone turnover rate in postmenopausal women with osteoporosis. |
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