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| 维生素K2（MK-7）防治骨质疏松的作用机制研究进展 |
| Update on the mechanism of vitamin K2 (MK-7) in preventing and treating osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2019.04.023 |
| 中文关键词: 维生素K2 MK-7 骨质疏松症 作用机制 |
| 英文关键词:vitamin K2 MK-7 osteoporosis mechanism |
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| 中文摘要: |
| 维生素K2具有抗骨质疏松的骨骼健康效应。在维生素K2系列中MK-7的活性最强。经成骨细胞、破骨细胞培养的体外机制分析及去卵巢骨质疏松模型、去神经骨质疏松模型、悬吊骨质疏松模型、肥胖骨质疏松模型和临床研究，揭示MK-7抗骨质疏松的作用机制：① 通过维生素K2依赖性蛋白的??-羧基化途径，将骨钙素分子中的谷氨酸残基羧化；② 通过刺激成骨细胞分化、调控骨细胞外基质矿化、上调骨标志物基因表达、抑制破骨细胞生成，促进骨形成和降低骨吸收。 |
| 英文摘要: |
| Vitamin K2 plays anti-osteoporosis effect on bone health. MK-7 has the strongest activity in vitamin K2 series. The mechanism of anti-osteoporosis of MK-7 was revealed by in vitro analysis of osteoblasts and osteoclasts culture, ovariectomized osteoporosis model, denervated osteoporosis model, suspended osteoporosis model, obese osteoporosis model and clinical research. The mechanism of anti-osteoporosis of MK-7:①??-Carboxylation of glutamate residue in osteocalcin molecule through the carboxylation pathway of vitamin K2-dependent protein;②Inhibiting osteoclast formation, promoting bone formation and reducing bone resorption, through stimulation of osteoblast differentiation, regulation of bone extracellular matrix mineralization and up-regulation of gene expression of bone markers. |
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