中国骨质疏松杂志

抑郁症和骨质疏松症关系的研究进展

Research progress on the association between depression and osteoporosis

DOI：10.3969/j.issn.1006-7108.2019.04.025

英文关键词:depression osteoporosis sympathetic nervous system vitamin D leptin

基金项目:上海市市级医疗卫生优秀学科带头人培养计划资助（2018BR03）；国家自然科学基金（81730107, 81774329）；上海市自然科学基金（17ZR1430800）；龙医创新团队（LYCX-01）

作者	单位
赫明超1,2 张勇3 连音3 王拥军1,2 张岩1,2*	1. 上海中医药大学附属龙华医院，上海 200032 2. 教育部筋骨理论与治法重点实验室，上海 200032 3. 深圳平乐骨伤科医院，广东深圳 518000

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中文摘要:

抑郁症是骨质疏松症的重要危险因素之一。抑郁症患者的骨密度比正常人低，更易发生骨量减少、乃至骨质疏松症。抑郁症患者骨量减少可能与交感神经系统、下丘脑-垂体-肾上腺轴、免疫系统、维生素D、瘦素、抗抑郁药有关。本文将对抑郁症和骨质疏松症关系的研究进展进行综述。

英文摘要:

Depression is one of the important risk factors for osteoporosis. Bone mineral density was lower in patients with depression than that of healthy people, thus, osteopenia, and even osteoporosis are more prone to occur in patients with depression. Osteopenia in patients with depression may be attributed to sympathetic nervous system, hypothalamus-pituitary-adrenal gland, immune system, vitamin D, leptin, and drugs for anti-depression. This review summarized the research progress on the relationship of depression and osteoporosis.

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