| Objective To explore the pathogenesis of alcohol-induced osteoporosis (AOP) in rats from the molecular gene level, to observe the effect of the generating marrow and strong-bone capsule on bone mineral density (BMD) and bone mineral content (BMC) in AOP rats, and to discuss the preventive and therapeutic mechanism of generating marrow and strong-bone capsule in AOP rats. Methods One hundred and twenty adult male SD rats (clean grade) were weighted and randomly divided into 4 groups, with 30 rats in each group. The rats were modelled with Red Star Erguotou liquor gavage method. At the same time, normal saline, calcium carbonate alfa-D3 and generating marrow and strong-bone capsule were gavaged, respectively. On 8, 12, and 16 weeks, BMD and BMC of the upper femur were detected. Results Software SPSS 22.0 was used for statistical analysis (P<0.05) and t test was performed. The changes of BMD and BMC at 8, 12 and 16 weeks after modeling intervention were detected. BMD and BMC in model group and normal group decreased significantly, and there was significant difference (P<0.01). The results showed that there was a decrease in bone mass and BMD and BMC in rats taking alcohol. Compared with model group, BMD and BMC in Chinese medicine intervention group increased significantly (P<0.01). Compared with western medicine control group, BMD and BMC increased significantly (P<0.05). Conclusion By observing the experimental index of the generating marrow and strong-bone capsule on AOP rats, it is proved that the generating marrow and strong-bone capsule increases BMD and BMC, inhibits mineral loss, and improves bone metabolism in AOP rats. |