| Objective To study the correlation between iron excess and bone metabolism and inflammatory response in postmenopausal women. Methods A total of117 postmenopausal women were divided into normal (T≥-1), bone loss (BL)(-2.5＜T＜-1) and osteoporosis group(T≤-2.5) according to BMD. Serum biochemical indicators including calcium (Ca), phosphorus (P), 25-hydroxyvitamin D (25-OH), white blood cell count (WBC), hemoglobin, glucose, C-reactive protein (CRP), creatinine, uric acid, alanine aminotransferase (ALT), and aspartate aminotransferase (AST) were measured in all patients. Iron metabolism indicators, Fer and TRF, as well as serum bone metabolism indicators β-CTX and PINP were determined. Results With the age increase of the postmenopausal women, the serum ferritin and iron excess elevated in the body, and the risk of osteoporosis increased along with the increase of β-CTX, PINP, and CRP. The serum ferritin is negatively correlated with BMD, but is positively correlated with β-CTX, PINP, and CRP. Conclusion Iron excess in postmenopausal women is accompanied by chronic inflammatory reaction. It promotes the degradation of type I collagen and accelerates the process of osteoporosis. |