| Estrogen deficiency is the main cause of postmenopausal osteoporosis. Estrogen or estrogen receptor modulators bind to estrogen receptors and through various molecular biological mechanisms to inhibit osteoclast bone resorption, to promote osteoblast bone formation, and to increase bone mineral density, resulting in the treatment postmenopausal osteoporosis. This article reviews the regulation mechanism of estrogen, selective estrogen receptor modulators and estrogen receptors on bone metabolism, animal studies of estrogen in the treatment of osteoporosis, and clinical progress of estrogen in the treatment of osteoporosis, in order to provide a scientific basis for the treatment strategy of osteoporosis. |