| Objective To systematically evaluate the efficacy of ossotide injection in the treatment of primary osteoporosis. Methods According to meta-analysis requirements, data in CBM, CNKI, PubMed, Springer, Embase databases, Cochrane Library, Chinese technical paper statistics and analysis, and patent databases were searched. The clinical studies on the treatment of primary osteoporosis with ossotide injection as the main intervention measure were enrolled from database founded to August 2018. All the information was extracted independently by two researchers and assisted and resolved by a third party if there gets some disagreement. The effectiveness and bone mineral density (BMD) were evaluated systematically by using the software named Review Manager 5.3, Stata/IC 15.0 and R language. Results Twenty literatures were finally included, and a total of 2,230 subjects are enrolled. Adverse reactions were reported in6 studies. The total effective rate was reported in 16 literatures, Chi2=16.98, I2=12%, P=0.32＞0.1, OR=6.17, 95% CI (4.74,8.04), P＜0.01, and the difference was statistically significant. Funnel plot, Egger, and Begg's test showed no obvious publication bias. The changes of BMD after taking the medication were reported in 10 literatures, showing that the heterogeneity of BMD of lumbar vertebrae after treatment is greater. Subgroup analysis, Galbraith heterogeneity test analysis, and Meta regression analysis were used to find the sources of heterogeneity. There were 6 literatures that reported the BMD analysis of the hip, SMD=0.18, 95% CI (0.02,0.34), Z=2.20, P=0.03<0.05, and the difference was statistically significant. Conclusion Ossotide injection is effective and safe in the treatment of primary osteoporosis. |