| Objective To investigate the correlation between serum thyroid stimulating hormone and osteoporotic fracture in postmenopausal women. Methods A total of4073 residents aged over 40 years old from Yunyan District, Guiyang City were investigated with questionnaire, physical examination, determination of serum TSH, and ultrasonic bone mineral density measurement of the calcaneus. According to the baseline TSH level, the subjects were divided into three groups: low (TSH<0.55 mIU/L, n=71), normal (0.55 mIU/L ≤ TSH ≤ 4.78 mIU/L, n=3113), or high (TSH>4.780 mIU/L, n=889). The baseline characteristics of each group were compared. After 3 years of follow-up, the correlation between different TSH levels and osteoporotic fractures was analyzed according to whether fractures occurred during the follow-up period. Results The number of newly developed osteoporosis fractures in the lower TSH group, the normal TSH group, and the higher TSH group were 8, 148, 51, respectively. The incidence was 11.3%, 4.8%, and 5.7%, respectively. The incidence of fracture in the lower TSH group was higher than that in normal TSH group (P＜0.17). In addition, BMD T-score≤ -2.5(OR=1.822, 95%CI 1.124-2.954, P=0.004), dyslipidemia (OR=1.381, 95%CI 1.038-1.836, P=0.034), TSH<0.55 mIU/L (OR=2.469, 95%CI 1.163-5.243, P=0.019) were risk factors of osteoporotic fracture. Compared with that in the normal TSH group, the risk of fracture in the lower TSH group was increased by 2.626 times (OR=2.626, 95%CI 1.233-5.592, P=0.012) after adjusting dyslipidemia and BMD T-score≤ -2.5. Conclusion Lower TSH levels are associated with an increased risk of osteoporotic fracture in postmenopausal women. |