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| 血清锌、铜和脂质水平与绝经后妇女骨密度相关性研究 |
| Relationship between serum zinc, copper, lipid levels, and bone mineral density in postmenopausal women |
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| DOI：10.3969/j.issn.1006-7108.2019.06.016 |
| 中文关键词: 绝经后骨质疏松症 骨密度 血脂 锌 铜 |
| 英文关键词:postmenopausal osteoporosis bone mineral density lipids zinc copper |
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| 中文摘要: |
| 目的 比较绝经后骨质疏松症女性和健康对照人群的血清锌（Zn）、铜（Cu）和血脂水平，并确定上述参数与骨密度（bone mineral density，BMD）之间是否存在关联。方法 研究对象为116名绝经后妇女，包括58例骨质疏松症患者[骨质疏松组，年龄（58.9±3.7）岁]和58名对照者[健康对照组，年龄（55.1±1.9）岁]。使用原子吸收分光光度法测定血清锌和铜含量，通过双能X线骨密度仪检测所有女性腰椎(L1~4)和左侧股骨颈的骨密度。结果 两组患者血清锌和铜含量相近（P＞0.05）;骨质疏松组血清低密度脂蛋白（LDL）和总胆固醇（TC）水平与对照组相比差异有统计学意义（P＜0.05）;相关分析显示体质量指数（bone mass index, BMI）与BMD值之间存在显著相关性（P＜0.05）；血清Zn、Cu水平与血脂无显著相关性（P＞0.05）;BMD与LDL（r=-0.302，P=0.002）和总胆固醇水平（r=-0.252，P=0.007）之间呈负相关。结论 本研究表明血脂异常可能是绝经后妇女骨质疏松症的独立危险因素。此外，微量元素对BMD没有直接和相关的影响。 |
| 英文摘要: |
| Objectives To compare the serum levels of zinc (Zn), copper (Cu), and lipid levels between the postmenopausal women with osteoporosis and the healthy controls. Furthermore, we aimed to determine whether there is an association between the above parameters and bone mineral density (BMD). Methods The study was conducted on 116 postmenopausal women, including 58 osteoporosis patients (age 58.9±3.7 years old) and 58 healthy controls (age 55.1±1.9 years old). The serum levels of Zn and Cu were measured using atomic absorption spectrophotometry. BMD of the lumbar vertebrae and the left femoral neck was examined with DEXA scan. Results The serum levels of Zn and Cu were similar in both groups (P>0.05). Serum levels of low density lipoprotein (LDL) and total cholesterol (TC) in osteoporosis group was statistically different compared to those in controls (P<0.05). Correlation analysis showed that there was significant association between body mass index (BMI) and BMD values (P<0.05). There was no correlation between serum Zn, Cu levels with lipid levels (P>0.05). However, significantly negative correlations between BMD with LDL (r=-0.302, P=0.002) and total cholesterol levels (r=-0.252, P=0.007) were found. Conclusion This study suggests that dyslipidemia might be an independent risk factor of osteoporosis in postmenopausal women. Moreover, the trace elements have no direct and correlative influence in BMD. |
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