| Objective To observe the clinical efficacy of Zhong Huang granule combined with posterior lumbar interbody fusion (PLIF) in the treatment of Lumbar Disc Herniation of Liver-Kidney Asthenia type complicated with osteopenia, and to further explore the clinical mechanism of this method. Methods From May 2014 to June 2017, 96 cases with Lumbar Disc Herniation of Liver-Kidney Asthenia type complicated with osteopenia were selected, 48 cases in the treatment group were treated by PLIF combined with orally taking Zhong Huang granules. In the control group, 48 cases were treated by PLIF. ODI (Oswestry disability index) scores, bone density T-score and serum OPG (osteoprotegerin) levels were observed and recorded before and after treatment at 6 and 12 months, as well as the adverse events of non-fusion, fusion device settlement and screw loosening at the last follow-up. Results 42 patients in the treatment group were followed up, and 40 patients in the control group were followed up. Satisfactory clinical efficacy was achieved in both groups, but the treatment group was superior to the control group, with statistically significant difference. Conclusion Zhong Huang granule can increase the serum OPG level, improve bone density and long-term postoperative clinical efficacy, and reduce the incidence of postoperative screw loosening, fusion device settlement and non-fusion adverse events. |