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| 甲状旁腺激素(1-34)和阿仑膦酸钠治疗骨质疏松症合并类风湿关节炎疗效的对比研究 |
| Comparative study of the efficacy of parathyroid hormone (1-34) and alendronate in the treatment of osteoporosis complicated with rheumatoid arthritis |
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| DOI：10.3969/j.issn.1006-7108.2019.06.021 |
| 中文关键词: 甲状旁腺激素(1-34) 阿仑膦酸钠 类风湿关节炎 骨质疏松 骨密度 骨代谢 |
| 英文关键词:parathyroid hormone (1-34) alendronate rheumatoid arthritis osteoporosis bone mineral density bone metabolism |
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| 中文摘要: |
| 目的 比较甲状旁腺激素(parathyroid hormone，PTH)(1-34)和阿仑膦酸钠(alendronate，ALN)治疗骨质疏松症合并类风湿关节炎(rheumatoid arthritis，RA)女性患者的疗效。方法 选取98例于2017年2月至2017年11月在我院就诊诊断为骨质疏松症合并RA绝经后女性患者。按照治疗方案将患者分为PTH组和ALN组，两组患者分别接受特立帕肽或阿仑膦酸钠治疗，观察治疗6个月后两组患者骨密度和骨代谢指标的改变。结果 在两组治疗6个月后，腰椎的骨密度较治疗前均有显著增加(P＜0.05)。与ALN组相比，PTH组治疗6个月腰椎骨密度的平均变化百分比显然更高；而股骨颈骨密度仅在PTH组显著增加。结论 甲状旁腺激素(1-34)在短期治疗骨质疏松症合并类风湿女性患者时，效果较阿仑膦酸钠更佳。 |
| 英文摘要: |
| Objective To compare the efficacy of parathyroid hormone 1-34 (PTH) and alendronate (ALN) in the treatment of osteoporosis combined with rheumatoid arthritis (RA) in women. Methods 98 female patients diagnosed with osteoporosis and RA after menopause were enrolled in our hospital from February 2017 to November 2017. Patients were divided into PTH group and ALN group according to the treatment plan. The two groups were treated with teriparatide or alendronate, respectively. The changes of bone mineral density and bone metabolism were observed after 6 months of treatment. Results After 6 months of treatment, the bone mineral density of lumbar spine increased significantly (P<0.05). Compared with the ALN group, the mean percentage change of lumbar spine BMD in the PTH group was significantly higher at 6 months of treatment; while the femoral neck BMD was only significantly increased in the PTH group. Conclusion Parathyroid hormone (1-34) is more effective than alendronate in the short-term treatment of osteoporosis combined with rheumatoid arthritis in women. |
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