| Objective To understand the correlation between disease history and osteoporosis in the elderly in Suzhou community through epidemiological investigation. Methods An on-site questionnaire was used to investigate the subject's basic data (including gender, age, height, and weight) and disease history (including high lipid level and drug use, resection of stomach/duodenum, hyperthyroidism/hypothyroidism, renal insufficiency, anemia, cancer, use of steroid, and other diseases). Bone mineral density (BMD) of the hip, lumbar vertebrae, and femoral neck was measured in 5527 elderly people (65-96 years old) using a dual-energy X-ray absorptiometry (DXA). The BMD T-score was used as the dependent variable for one-way regression analysis and subset regression variable selection. The linear regression model based on Elastic Net was generalized for multiple response variable selection. Results Resection of stomach/duodenum, other orthopedic diseases, and hypolipidemic drug intake were included in the optimal model with the hip BMD T-score as the dependent variable (the adjusted decision coefficient was optimal). Hyperlipidemia, hyperthyroidism, renal insufficiency, and anemia were included in the optimal model of the lumbar spine BMD T-score as the dependent variable (the adjusted decision coefficient was optimal). Resection of stomach/duodenum, renal insufficiency, and anemia were included into the femoral neck BMD T - score as the dependent variable of the optimal model of the optimal (adjust the coefficient of determination). Elastic Net variable screening showed that hyperlipidemia, long-term use of hyperlipidemic drugs, resection of stomach/duodenum, renal insufficiency, anemia, cancer, long-term use of steroid hormones, and other orthopedic diseases were correlated with BMD T-scores. However, short-term use of hypolipidemic drugs and corticosteroids were not correlated with BMD T-score. Conclusion In the elderly population, the history of many diseases is closely related to osteoporosis, suggesting that BMD measurement and disease screening should be carried out regularly in the elderly over 65 years old with the listed diseases in order to effectively prevent the occurrence of osteoporosis. |