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| 骨硬化蛋白和dkk1与2型糖尿病患者骨密度相关性研究 |
| Correlation between osteosclerosis and dkk1 and bone mineral density in type 2 diabetic patients |
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| DOI：10.3969/j.issn.1006.7108.2019.07.008 |
| 中文关键词: 2型糖尿病 骨密度 骨硬化蛋白 DKK1 骨重塑 |
| 英文关键词:type 2 diabetes mellitus bone mineral density sclerostin dkk1 bone remodeling |
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| 中文摘要: |
| 目的 探讨骨硬化蛋白和dkk1与2型糖尿病患者骨密度相关性。方法 这项横断面研究包括190名患有2型糖尿病的住院患者。我们根据不同的BMD水平将患者分为三组(即正常骨密度组，骨量减少组和骨质疏松组)，并测量血清中骨硬化蛋白、dkk1、25-羟基维生素D 3(25OHD3)的水平，每组的骨转换标志物和其他生化数据。结果 在骨质疏松症组中发现血清骨硬化蛋白和dkk1水平显著增加，即使分别考虑男性和女性群组。回归分析表明，在调整年龄、性别和25OHD3后，血清硬化蛋白水平与骨质减少和骨质疏松症存在独立相关。BMD与血清骨硬化蛋白和dkk1水平呈负相关，与25OHD3呈正相关。此外，年龄、糖化血红蛋白和血清骨硬化蛋白水平是1型前胶原氨基末端前肽(N-propeptide of type 1 collagen, P1NP)的预测因子，血清dkk1水平是1型胶原交联羧基末端肽(C-terminal crosslinking telopeptides of type 1 collagen, 1CTP)的唯一预测因子。结论 骨硬化蛋白和dkk1水平随着骨质疏松症2型糖尿病患者BMD的降低而增加。 |
| 英文摘要: |
| Objective This study was designed to investigate the association between osteosclerosis and bone mineral density in patients with dkk1 and type 2 diabetes. Methods This cross-sectional study included 190 in-patients with type 2 diabetes mellitus. We divided the patients into three groups, the normal bone mineral density (BMD) group, osteopenia group, and osteoporosis group, based on their different BMD levels. The serum levels of sclerostin, dkk1, 25-hydroxyvitamin D3 (25OHD3), bone turnover markers, and other biochemical indexes were measured in each group. Results Significantly increased levels of serum sclerostin and dkk1 were found in the osteoporosis group, even when the male and female cohorts were considered separately. Ordinal logistic regression analysis suggested that the level of serum sclerostin were independently associated with the presence of osteopenia and osteoporosis after adjusting for age, gender and 25OHD3. The areal BMDs were negatively correlated with the levels of serum sclerostin and dkk1 and positively correlated with 25OHD3. In addition, age, glycosylated hemoglobin and serum sclerostin levels were predictors for N-terminal propeptide of type 1 procollagen, and serum dkk1 levels were the only predictors for crosslinked carboxyterminal telopeptide in type 1 collagen. Conclusion Osteosclerosis and dkk1 levels increase with decreasing BMD in osteoporotic patients with type 2 diabetes. |
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