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| 血清维生素E水平与绝经后早期女性骨密度相关性研究 |
| Correlation between serum vitamin E levels and bone mineral density in the early stage of postmenopausal women |
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| DOI：10.3969/j.issn.1006.7108.2019.07.015 |
| 中文关键词: 骨密度，骨质疏松症，维生素E，早期绝经后妇女 |
| 英文关键词:bone mineral density osteoporosis, vitamin E early stage of postmenopausal women |
| 基金项目: |
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| 中文摘要: |
| 目的 评估绝经后早期妇女维生素E水平与骨质疏松症之间的关系。方法 收集人体测量数据，骨质疏松症的危险因素，维生素E血清水平，和其他可能影响绝经后妇女骨密度的血清参数。通过多变量逻辑回归和多元线性回归分析232名绝经后早期女性骨质疏松症与年龄、绝经年龄、体质量指数、骨钙素、钙、维生素D和维生素E(分别以25羟维生素D和α-生育酚：脂质比率测定)、骨碱性磷酸酶、吸烟状况、体力活动和饮酒量之间的关系。结果 在多变量逻辑回归中，较低的维生素E：脂质比率与骨质疏松症相关。在腰椎BMD作为因变量的多变量线性模型中，维生素E：脂质比率与腰椎BMD明显相关(F比率= 6.28，P= 0.001)。腰椎的BMD在维生素E：脂质比率的最高三分位数中显著高于最低三分位数。使用多变量调整的BMD后，绝经后女性(3.1±0.5 μmol/mmol)的绝经后女性（3.6±0.6 μmol/mmol)的平均维生素E：脂质比率显着低于正常(无骨质疏松症和骨质减少)。结论 本研究表明维生素E可能会增加健康绝经后妇女的骨密度。 |
| 英文摘要: |
| Objective To evaluate the relationship between vitamin E status and osteoporosis in early stage of postmenopausal women. Methods Anthropometric data, osteoporosis risk factors, vitamin E serum levels, bone mineral density (BMD), and other serum parameters which may influence BMD in postmenopausal women were collected in a cross-sectional study. The association between osteoporosis and age, age of menopause, body mass index, osteocalcin, calcium, vitamin D, vitamin E (measured as 25 hydroxyvitamin D and as α-tocopherol/lipids ratio, respectively), bone alkaline phosphatase, smoking status, leisure physical activity, and alcohol intake were analyzed using a multivariate logistic regression and multi-linear regression analysis in 232 early postmenopausal women. Results A lower vitamin E/lipid ratio was associated with osteoporosis in multivariate logistic regression. In a multivariate linear model with BMD of the lumbar spine as a dependent variable, the vitamin E/lipid ratio was clearly related with BMD of the lumbar spine (F ratio = 6.28, P = 0.001). BMD of the lumbar spine was significantly higher in the highest tertial of the vitamin E/lipid ratio than in the lowest tertial. The mean vitamin E/lipid ratio was significantly lower in osteoporotic postmenopausal women (3.1±0.5 μmol/mmol) than normal (neither osteoporotic nor osteopenic) postmenopausal women (3.6±0.6 μmol/mmol) using multivariable-adjusted BMD. Conclusion These findings highlight that vitamin E may increase BMD in healthy postmenopausal women. |
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