|
| 细胞外囊泡与衰老的关系及其在骨代谢疾病中的研究进展 |
| The relationship between extracellular vesicles and aging and its research progress in bone metabolic diseases |
| |
| DOI：10.3969/j.issn.1006.7108.2019.07.031 |
| 中文关键词: 细胞外囊泡 骨代谢 细胞衰老 衰老相关分泌表型 |
| 英文关键词:extracellular vesicles bone metabolic cellular senescence SASP |
| 基金项目:国家自然科学基金（81470716） |
|
| 摘要点击次数: 1215 |
| 全文下载次数: 449 |
| 中文摘要: |
| 随着老龄化社会的到来，骨质疏松等骨代谢性疾病越来越受到人们的重视。细胞衰老已被证明是导致骨代谢过程中骨量丢失的重要原因之一，其中细胞外囊泡是由细胞分泌的在细胞间传递信息的重要媒介，囊泡内含有不同种类的miRNAs、蛋白质、脂质、mRNAs、tRNAs等生物活性物质，在细胞信息交流中起着重要作用，目前被认为具有与衰老相关分泌表型，即SASP因子相似的功能。本文将总结近年来机体或细胞在衰老时分泌的细胞外囊泡与SASP因子之间关系的研究进展，并展望细胞外囊泡在未来衰老引起的骨代谢性疾病治疗研究中存在的潜在价值。 |
| 英文摘要: |
| With the aging society coming, bone metabolic diseases such as osteoporosis have attracted more and more attention. Cell senescence has been proved to be one of the important causes of bone loss in bone metabolism. Extracellular vesicles are the important mediators secreted by cells to transmit information between cells. Vesicles contain different kinds of microRNAs, proteins, lipids, mRNAs, tRNAs, and other bioactive substances, which play an important role in cell information exchange. They are currently considered to have a similar function to the aging-related secretory phenotype, namely SASP factor. This article summarizes the research progress of the relationship between extracellular vesicles secreted by organisms or cells during aging and SASP factors in recent years, and looks forward to the potential value of extracellular vesicles in the treatment of bone metabolic diseases caused by aging in the future. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |