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| 不同年龄髋部、腰部肌肉含量与对应骨密度相关性分析 |
| Analysis of correlation between muscle content of the hip and waist and bone mineral density in different age groups |
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| DOI：10.3969/j.issn.1006-7108.2019.08.001 |
| 中文关键词: 骨密度 肌肉含量 骨质疏松症 相关性 |
| 英文关键词:bone mineral density muscle content osteoporosis correlation |
| 基金项目:国家自然科学基金（81572179）；苏州市民生科技项目（SS201814）；苏州大学附属第二医院优势学科群项目（XKQ2015001）；国家自然基金预研基金（SDFEGJ1601） |
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| 中文摘要: |
| 目的 了解50岁以上体检人群局部肌肉含量（髋部、腰部）与相应骨密度变化趋势，分析不同年龄段局部肌肉含量与骨密度之间的相关性。方法 收集苏州大学附属第二医院2008年6月至2013年12月50岁以上体检人群8 305例资料，整理双能X线骨密度仪（DXA）检测的骨密度数据（腰椎和髋部），同时整理每人“骨密度局部模式”所检测的“腰椎周围”“髋部周围”肌肉比值数据；按性别分男女两组，两组再按年龄分为50~59、60~69、70~79、≥80岁四个亚组，用折线图显示局部肌肉含量及相应骨密度随年龄变化趋势，用偏相关分析、多元线性回归方法分析局部肌肉含量与相应骨密度的关系。结果 ①髋部肌肉含量与股骨颈骨密度关系：50~59、60~69岁两个年龄段中，男性及女性具有正相关，有统计学意义（P<0.05）；70~79、≥80岁两个年龄段中，男性及女性无相关性；②腰部肌肉含量与腰椎骨密度关系：仅在男性70~79岁年龄段中具有负相关关系（P<0.05），其余各组无相关性。结论 50岁以上人群中，在70岁之前，髋部肌肉含量对股骨颈骨密度影响显著，70岁之后，髋部肌肉含量对股骨颈骨密度影响不显著；所以，在肌少症与骨质疏松症相关范畴，建议50~70岁人群应关注下肢肌肉含量提高，以利骨量提高；70岁以上老年人群，应更关注下肢肌肉含量之外骨质疏松症危险因素预防。 |
| 英文摘要: |
| Objective To investigate the change trend of the local muscle content (hip and waist) and bone mineral density (BMD) in people over 50 years old who had undergone physical examination, and to analyze the correlation between local muscle content and BMD in different age groups. Methods A cross-sectional study was conducted on 8 305 subjects over 50 years old who had undergone routine health examination at the Affiliated Second Hospital, Soochow University from June 2008 to December 2013. BMD of the lumbar spine and hip and local muscle content of the hip and waist were measured using dual-energy X-ray absorptiometry (DXA). The data of the muscle mass ratio around the spine and hip were collected according to the local BMD model. The subjects were divided into two groups according to the gender, and each group was further divided into 4 groups according to age (50-59, 60-69, 70-79, and ≥80 years old, respectively). The change trend of the local muscle content and BMD with age was shown with polygraph. The relationship between local muscle content and BMD was analyzed using partial correlation analysis and multiple linear regression. Results ① There was a positive relationship between muscle content of the hip and BMD of the femoral neck in both males and females at 50-59 and 60-69 years old (P<0.05), but there was no correlation at 70-79 and ≥80 years old. ② A negative correlation between muscle content of the waist and BMD of the lumbar spine was found in males at 70-79 years old (P<0.05), but no correlation was found in other groups. Conclusion Before 70 years old, the muscle content of the hip has a significant effect on femoral neck BMD among people over 50 years old, but the effect disappears after 70 years old. Therefore, in order to improve bone mass, we suggest that people aged 50-70 should pay attention to the improvement of muscle content of the lower limb. More attention should be paid to prevent risk factors of osteoporosis in the elderly over 70 years old. |
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