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| 中老年体检人群血清铁蛋白增加与骨量变化的相关性分析 |
| Correlation analysis between increased serum ferritin and bone mass in older population in healthy examination |
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| DOI：10.3969/j.issn.1006-7108.2019.08.003 |
| 中文关键词: 女性 骨密度 铁蛋白 相关性 |
| 英文关键词:females bone mineral density ferritin correlation |
| 基金项目:国家自然科学基金（81572179）；苏州市民生科技项目（SS201814）；苏州大学附属第二医院优势学科群项目（XKQ2015001）；国家自然基金预研基金（SDFEGJ1601） |
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| 中文摘要: |
| 目的 通过分析50岁以上体检人群的各项指标与骨密度指标关系，了解血清铁蛋白增加与骨量改变的相关性。方法 收集2011年1月至2017年12月年龄大于50岁来本院进行“全指标”健康体检数据，共2 602例，“全指标”包括：①年龄、身高、体重、腰围、血压；②血清生化指标、血清肿瘤指标；③腰椎和股骨颈骨密度。分析各项指标与骨密度关系，分析血清铁蛋白对骨量改变的影响。结果 多重线性回归和多元Logistics回归分析显示：①年龄、腰围和ALP是引起男女性骨量（腰椎或股骨颈）下降的危险因素，身高、体质量指数（bone mass index, BMI）和收缩压是骨量保护因素；②血清铁蛋白是50岁以上女性骨密度下降的独立危险因素，其浓度的上升会进一步导致50岁以上女性骨量减低或骨质疏松风险增加。结论 50岁以上女性体内铁蛋白上升会进一步增加骨质疏松症的发生风险；高龄、高ALP是50岁以上男女性骨量下降的危险因素，增加BMI、身高高度对骨量具有一定保护作用。 |
| 英文摘要: |
| Objective To analyze the correlations between the gender- and body-site-specific factors and bone mineral density (BMD) at the lumbar spine and femoral neck in population aged ≥50 years and older, and to investigate the association between the increased serum ferritin and the change of bone mass. Methods A total of 2 602 subjects who had undergone comprehensive routine health examinations in our hospital from January 2011 to December 2017 were enrolled in this study. The comprehensive data included: ① age, height, weight, waist circumference, and blood pressure; ② biochemical markers and serum tumor markers; ③ BMD of the lumbar spine and femoral neck. The relationship between various indicators and BMD was analyzed. The effect of serum ferritin on bone mass was analyzed. Results Multiple linear regression and multivariate logistics regression analysis showed : ① Age, waist circumference, and ALP were the risk factors for the decrease of bone mass (lumbar spine or femoral neck) in men and women, and height, BMI, and systolic pressure were the protective factors of bone mass; ② Serum ferritin was independent risk factor for the decrease of BMD in women over 50 years old, and increased serum ferritin was an important factor for risk of osteopenia or osteoporosis in women over 50 years of age. Conclusion The increase of ferritin in women over 50 years of age increases the risk of osteoporosis. In addition, the elder age and high ALP are both risk factors of bone mass loss in males or females over 50 years old. The increase of BMI or height may have a certain protective effect on bone mass. |
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