| Objective To study the relationship between the ratio of neutrophil to lymphocyte ratio (NLR) and osteoporosis, and to evaluate its diagnostic value for osteoporosis. Methods A retrospective analysis of patients with osteoporosis treated in our hospital was performed. Age, weight, sex, white blood cell count, red blood cell count, lymphocyte count, neutrophil count, monocyte count, platelet count, hemoglobin volume, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), bone mineral density (BMD), and NLR levels were examined. The diagnostic value of NLR was calculated with ROC curve. The correlation between NLR and other indicators was detected with Pearson analysis. Results The majority of patients with osteoporosis were female patients. The white blood cells, neutrophils, and monocytes in osteoporotic patients were significantly higher than in the control group, but BMD and lymphocyte levels were significantly lower (P<0.05). The CRP level was higher than the normal range. ESR, alanine aminotransferase, aspartate aminotransferase, and uric acid were all within the normal range. The level of NLR in patients with osteoporosis (2.23±1.65) was significantly higher than that in the normal control group (1.56±0.54), and the difference was statistically significant (P<0.05). AUC of was 0.747, with a cut-off value of 0.436, a sensitivity of 0.629, and a specificity of 0.807 (95% CI: 0.682-0.813), which had a high diagnostic value. NLR was positively correlated with CRP and ESR (r =0.324, 0.305, P<0.05), but was negatively correlated with BMD (r=–0.250, P<0.05). It had no significant correlation with age. The correlation between NLR and CRP was better than that between NLR and BMD. Conclusion This study confirms that NLR can be used as a predictive diagnostic indicator for osteoporosis and has a clinical guiding role. |