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| 骨骼系统中糖代谢机制的运动干预研究 |
| Research on the mechanism of exercise intervention on glucose metabolism in the skeletal system |
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| DOI：10.3969/j.issn.1006-7108.2019.08.028 |
| 中文关键词: 成骨细胞 破骨细胞 葡萄糖代谢 能量 运动 |
| 英文关键词:osteoblast osteoclast glucose metabolism energy exercise |
| 基金项目:教育部重点实验室项目（40500-54123514203/004） |
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| 中文摘要: |
| 成骨细胞的骨形成功能和破骨细胞的骨吸收功能构成了骨重塑结构，其平衡过程是骨稳态的重要因素。然而，这种平衡可能会因为骨内稳态失衡而受到破坏，了解骨骼中葡萄糖代谢的作用和调节机制，可为进一步揭示成骨细胞和破骨细胞的分化过程提供更宽阔的视角。文献表明，PTH、胰岛素、IGFs、Wnt信号通路均会对成骨细胞中的糖酵解过程产生作用。破骨细胞中的糖酵解和氧化磷酸化过程，会引起RANKL水平激增，进而维持骨稳态。此外，确定糖代谢与成骨细胞和破骨细胞的生长因子及转录因子之间的联系，为运动干预提供媒介，将有助于阐明运动调节糖代谢与骨代谢的共同机制，为新型治疗方法开辟新的途径。 |
| 英文摘要: |
| Osteogenesis of osteoblasts and bone resorption of osteoclasts constitute a bone remodeling structure, and the balance process is an important cause of bone homeostasis. However, this balance may be compromised due to an imbalance in bone homeostasis. Understanding the role and regulation of glucose metabolism in bone may provide a broader perspective for further revealing the differentiation process of osteoblasts and osteoclasts. The literature shows that PTH, insulin and IGFs, and Wnt signaling pathways contribute to glycolysis in osteoblasts. Glycolysis and oxidative phosphorylation in osteoclasts could cause an increase in RANKL level, which in turn maintains bone homeostasis. In addition, determining the relationship between glucose metabolism and growth factors and transcription factors of osteoblasts and osteoclasts provides a vehicle for exercise intervention, which will not only help to elucidate the common mechanism of exercise regulation on glucose metabolism and bone metabolism, but also for the development of new treatment methods and opened up new avenues. |
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