Objective To study the effect of hyperbaric oxygen combined with local injection of nerve growth factor on the expression of serum adhesion factor and microcirculation in patients with delayed union of osteoporotic fractures. Methods Eight-four osteoporotic fracture cases with delayed healing were divided into control group and observation group, with 42 cases in each group. Patients in both groups received routine therapy. In addition, patients in the observation group received hyperbaric oxygen therapy and intramuscular injection of nerve growth factor (NGF) around the fracture. The fracture healing between the two groups was compared. The hemorheology indexes (erythrocyte aggregation index and plasma viscosity), erythrocyte rigidity index, serum adhesion factor [serum soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1)], bone morphogenetic protein-2 (BMP-2), and the protein expressions of transforming growth factor (TGF-β1), insulin-like growth factor-1 (IGF-1), platelet derived growth factor (platelet derived growth factor-PDGF), and OPG/RANKL before and after the treatment were compared. Results At 1 month, 2 months, 3 months, and 6 months after the treatment, the fracture healing rate in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the erythrocyte aggregation index, plasma viscosity, and erythrocyte rigidity index in the observation group were significantly higher than those in the control group (P< 0.01). The levels of sICAM-1, BMP-2, and sVCAM-1 in the observation group were significantly higher than those in the control group (P < 0.01). The levels of TGF- β1, IGF-1, and PDGF in the observation group were significantly higher than those in the control group (P<0.01). The expression of OPG/RANKL protein in the observation group was significantly higher than that in the control group (P<0.05). Conclusion Local injection of hyperbaric oxygen combined with nerve growth factor significantly improves serum adhesion factor and microcirculation index in patients with delayed union of osteoporosis fracture, and promotes fracture healing, which is worthy to apply in the clinic. |