| Objective To investigate the effect of the ethanol extract of morinda officinalis on trabecular status, bone mineral density (BMD), and maximum load of bone tissue in ovariectomized rats with high-fat diet. Methods The postmenopausal osteoporosis model was established by removing both ovaries of female SD rats. The rats are randomly divided into the sham operation group, the normal diet model group, the high-fat diet model group, and the morinda officinalis group. Rat in morinda officinalis group were fed with ethanol extract of morinda officinalis, and other rats were fed with normal saline. BMD was detected with dual-energy X-ray densitometry. Maximum load of bone tissue was tested with material testing machine. Bone morphology was observed after Masson staining. Results Compared with the sham operation group, BMD and maximum load of bone tissue decreased in the ovariectomy group (P<0.05), and the microstructure of bone changed significantly, especially in the high-fat diet model group. Compared with the morinda diet group, BMD and maximum load of bone tissue decreased in other ovariectomy groups, and the microstructure of bone changed (P<0.05). Conclusion High-fat diet damages the bone mass and microstructure of ovariectomized rats. Ethanol extract of morinda officinalis inhibits bone loss in obese ovariectomized rats, protects the microstructure of the bone, and increases the maximum load of the bone. |