| Objective To investigate the changes of glycolipid metabolism and bone mineral density (BMD) in patients with subclinical hypothyroidism (SCH). Methods A total of 120 patients with perimenopausal SCH who were admitted to the endocrinology department of our hospital from January 2016 to August 2018 were enrolled as the study group. One hundred and twenty perimenopausal healthy women who were admitted to the physical examination center of our hospital at the same period were selected as the control group. Fasting venous blood was collected from the subjects of the two groups. TSH, FT3, FT4, TC, TG, HDL, and LDL were detected and compared. Oral glucose tolerance and CP release test in patients of the two groups were detected. BMD of the lumbar vertebrae L2-4, total hip, left femoral neck, and left greater trochanter was examined. Pearson correlation analysis was used to evaluate the relationship among TSH level, glucose and lipid metabolism, and BMD. Results The levels of TSH, TC, TG, LDL, CP0, CP1h, CP2h, FPG, PBG1h, and PBG2h in the study group were significantly higher than those in the control group, and the difference was statistically significant (P<0.05). HDL and BMD of the lumbar vertebra L2-4, total hip, left femoral neck, and left greater trochanter in the study group were significantly lower than those in the control group, and the difference was statistically significant (P<0.05). The serum level of TSH was significantly positively correlated with serum levels of TC, TG, LDL, FPG, PBG1h, PBG2h, CP0, CP1h, and CP2h (P<0.05). Serum TSH level in the study group was negatively correlated with serum HDL and BMD of the lumbar vertebrae L2-4, total hip, left femoral neck, and left greater trochanter BMD (P<0.05). Conclusion The perimenopausal SCH patients have disordered glycolipid metabolism and decreased BMD. The SCH level is closely related to glycolipid metabolism and BMD. |