| Nicotine (C10H14N2) is a plant alkaloid derived from tobacco plants and is the main component of tobacco. When smoking, nicotine enters the blood system through the mucous membranes and is distributed in free form to other body tissues. It causes damage to multiple systems of the body by promoting the release of neurotransmitters, reducing antibody production, affecting peripheral immune functions and calcium and phosphorus metabolism. This article summarizes the research progress in the effect of nicotine on the skeletal system and the mechanism, and provides clues for the future study of the effect of nicotine on osteoporosis, fractures, oral implants, artificial joints, and withdrawal reaction of nicotine. |