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| 基于“脾主肉、肾主骨”理论探讨绝经后骨质疏松症的OPG/RANK/RANKL信号调控机制 |
| Study on the mechanism of OPG/RANK/RANKL signal regulation on postmenopausal osteoporosis based on the spleen governing muscle and kidney governing bone theory |
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| DOI：10.3969/j.issn.1006.7108.2019.09.026 |
| 中文关键词: 绝经后骨质疏松症 OPG/RANK/RANKL系统 雌激素 机制 脾肾同治 |
| 英文关键词:postmenopausal osteoporosis OPG/RANK/RANKL system estrogen mechanism joint treatment of spleen and kidney |
| 基金项目:国家自然科学基金（81760877）；兰州市人才创新创业专项（2018-RC-99） |
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| 中文摘要: |
| 中医理论传承“辨证论治”之道，强调人作为机体的整体性与统一性，肾主骨生髓为先天之本，脾主肌肉充四肢为后天之源，先后二天互资互生，共同维持人体正常的生理机能，但缺乏客观的分子生物学依据阐明其作用机理；OPG/RANK/RANKL信号转导系统的发现在骨代谢史上具有里程碑的意义，开创了中医药防治和研究绝经后骨质疏松症的新纪元，骨微观信息的改变就是从脾肾论治对骨代谢调控机制的效应表达。本文基于“脾主肉、肾主骨”理论，就绝经后骨质疏松症的病因病机及治法方药结合OPG/RANK/RANKL信号转导系统在骨代谢中的作用展开综述，旨在为绝经后骨质疏松症的中医药防治从分子生物学水平提供科学依据，以期更好地指导临床。 |
| 英文摘要: |
| The theory of TCM inherits the treatment according to differentiation principle, emphasizing the integrity and unity of human beings as a whole body. The kidney governing bone and producing marrow is the congenital essence. The spleen governing muscle and filling with limbs is the postnatal source. They are interdependency to jointly maintain the normal physiological function of the human body. However, there is lack of objective molecular biology basis to explain its mechanism of action. The discovery of the OPG/RANK/RANKL signal transduction system is a milestone in the history of bone metabolism, which creates a new era of the research of prevention and treatment of postmenopausal osteoporosis (PMOP) with traditional Chinese medicine. The change of bone microscopic information is to express the effect of the system on the regulation mechanism of bone from the spleen and kidney. Based on the theory of spleen governing muscle and kidney governing bone, this paper reviews the etiology and pathogenesis of postmenopausal osteoporosis and the role of OPG/RANK/RANKL signaling pathway in bone metabolism, which aims to provide a scientific basis for the prevention and treatment of PMOP with traditional Chinese medicine from the molecular biological level, and to guide clinical practice better. |
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