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| 唑来膦酸治疗骨质疏松症对心电影响的研究 |
| The study on the effect of zoledronic acid on electrocardiogram in the treatment of osteoporosis |
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| DOI：10.3969/j.issn.1006-7108.2019.10.009 |
| 中文关键词: 骨质疏松 唑来膦酸 心电参数 |
| 英文关键词:osteoporosis zoledronic acid electrocardiogram |
| 基金项目:福建省卫生计生委项目(2016-1-64)；福建省教育厅项目(JAT160205) |
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| 中文摘要: |
| 目的 观察使用唑来膦酸治疗骨质疏松是否对患者的心电产生影响。方法 采用前瞻性自身治疗前后的对照研究，观察90例原发性骨质疏松患者，年龄52～92岁，平均（68.3±9.7）岁，其中男性6例，女性84例。使用唑来膦酸前行血清生化学及常规心电图检查，静滴唑来膦酸（5 mg/100 mL）后再查常规心电图。比较使用唑来膦酸前后的心电参数，记录有意义心电图报告的改变。结果 受试者心脏的房率、室率在使用唑来膦酸后显著增快（P＜0.05）；QT间期使用唑来膦酸后显著缩短（P＜0.05）；P波时限、P-R间期、QRS波时限、QRS电轴、RV5+SV1、QTc使用唑来膦酸后的改变均没有统计学意义（P＞0.05）。由心律失常转变为无心律失常的良性变化病例2例（2.2%）；心电图提示不良变化8例（8.8%），其中房颤1例（1.1%）。结论 使用唑来膦酸治疗骨质疏松时发生严重心律失常如房颤的概率相对较小，总体来说在心电方面的安全性较高。 |
| 英文摘要: |
| Objective To observe the effect of zoledronic acid (ZA) on electrocardiographic parameters in osteoporosis patients. Methods A prospective self-control study was conducted to observe 90 patients with primary osteoporosis before and after treatment. Patients aged 52-92 years, with an average age of 68.3±9.7 years (6 males and 84 females). Serum biochemical examination and routine electrocardiogram (ECG) were performed before using intravenous zoledronic acid and routine electrocardiogram was examined after using intravenous zoledronic acid (5 mg/100 mL). ECG parameters were compared before and after intravenous ZA, and meaningful changes in ECG reports were recorded. Results The atrial rate and ventricular rate increased significantly after ZA infusion (P<0.05). The QT interval was significantly shortened after ZA infusion (P<0.05). There were no statistical differences in the variation of P wave duration, PR interval, QRS wave duration, QRS axis, RV5+SV1 and QTc (P>0.05). There were 2 cases with benign changes from arrhythmia to non-arrhythmia (2.2%). The ECG reports showed 8 cases of adverse changes (8.8%), including 1 case of atrial fibrillation (1.1%). Conclusion The probability of serious arrhythmias such as atrial fibrillation in the treatment of osteoporosis with zoledronic acid is relatively small, and the overall safety of zoledronic acid in electrocardiogram is relatively high. |
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