| Objective To explore the risk factors of postmenopausal osteoporosis (PMOP) and metabolic syndrome (MS) in women, and to provide the basis for their clinical prevention and treatment. Methods A total of 266 postmenopausal women who underwent physical examination at Liaocheng University Nutrition Center and Liaocheng People's Hospital from March 2017 to January 2018 were enrolled, including 122 postmenopausal non-osteoporosis (N-PMOP) patients and 134 patients with PMOP including 69 patients accompanied by MS (MS-PMOP). Data on bone mineral density (BMD) and lipid metabolism were collected, and the relationship between lipid metabolism index and BMD in PMOP and MS patients, and the risk factors of PMOP were statistically analyzed. Results The occurrence of MS-PMOP was positively correlated with height, high density lipoprotein (HDL-C), serum calcium (Ca) and serum phosphorus (P) (P<0.05), and was negatively correlated with age, fasting blood glucose (FPG), systolic blood pressure (SBP), diastolic blood pressure (DBP), low density lipoprotein (LDL-C) and blood homocysteine (HCY) (P<0.05). The age of patients in the PMOP and N-PMOP groups was significantly different, and SBP, DBP, FPG and HCY of patients in the PMOP group were significantly higher than those in the N-PMOP group (P<0.05). In addition, HDL-C of patients in the PMOP group was significantly lower than that in the N-PMOP group (P＜0.05). DBP, FPG, HDL-C and HCY of patients in the PMOP group were significantly lower than those in the MS-PMOP group (P<0.05). Logistic regression analysis showed an increase in SBP and FPG and a reduction of HDL-C were risk factors for PMOP. Conclusion Abnormal lipid metabolism and increased HCY may affect bone metabolism in postmenopausal women and increase the risk of PMOP. In addition, the increase in SBP and FPG, and the reduction of HDL-C are risk factors for PMOP. As agglomerates of various metabolic abnormalities, MS patients are at high risk for PMOP. |