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| 血清视黄醇与绝经后妇女骨密度和骨代谢指标的相关 性研究 |
| Correlation between serum retinol and bone mineral density and bone metabolism markers in postmenopausal women |
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| DOI：10.3969/j.issn.1006-7108.2019.10.013 |
| 中文关键词: 维生素A 视黄醇 骨质疏松症；骨质疏松症风险；骨量；骨骼健康 |
| 英文关键词:Vitamin A retinol osteoporosis osteoporotic risk bone mass bone health |
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| 中文摘要: |
| 目的 探讨血清视黄醇水平与绝经后妇女骨密度和骨代谢指标的相关性。方法 对154例绝经后骨质疏松症妇女（> 55岁）进行横断面研究，采用双能X线骨密度仪检测所有患者的骨密度（bone mineral density, BMD)，同时检测患者的血清视黄醇、骨钙素、甲状旁腺素、碱性磷酸酶、钙和磷的水平，分析其相关性。结果 Spearman分析显示患者视黄醇水平与腰椎BMD (r=?0.161，P<0.05)、股骨颈 BMD (r = ?0.181 ,P<0.05)、碱性磷酸酶( r=0.109,P <0. 05)、磷(r =?0.109, P <0. 05) 及生育时限(r = 0. 157,P <0.05)呈正相关。经过多变量调整后，仍然发现血清视黄醇与腰椎（r =?0.209,P<0.05)和股骨颈 (r=?0.324,P<0.05)的BMD呈负相关。结论 血清视黄醇水平升髙与低骨量的风险增加有关，因此，维生素A可能是骨质疏松症的危险因素之一。 |
| 英文摘要: |
| Objective To explore the correlation between serum retinol levels and bone mineral density and bone metabolism markers in postmenopausal women. Methods For this purpose, a cross-sectional study was carried out in 155 osteoporotic non?treated postmenopausal women (>55 years old). Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry. We assessed serum concentrations of retinol, osteocalcin, parathyroid hormone, alkaline phosphatase, calcium, and phosphorus. We also studied demographic and anthropometric parameters, and the correlation among the factors were analyzed. Results Spearman’s correlation analyses between retinol levels and other variables showed negative correlations with BMD at both lumbar spine (r= -0. 161, P<0. 05) and femoral neck ( r= -0. 181,P<0. 05)，as well as alkaline phosphatase ( r= -0. 109； P<0. 05) and phosphorus (r= -0. 109； P <0. 05). A positive correlation between retinol and fertile window was observed (r= 0. 157 ； P<0. 05). After multivariable adjustment, we still found a negative correlation between serum retinol and BMD, both at the lumbar spine ( r= -0. 209,P<0. 05) and at the femoral neck ( r= -0. 323, P<0. 05). Conclusion Elevated serum retinol levels are associated with an increased risk of low bone mass, so vitamin A may be one of the risk factors for osteoporosis. |
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