| Objective To understand the change of serum osteocalcin (OC) and the relationship between OC and energy metabolism in healthy population. Methods According to the exclusion criteria, 115 subjects were selected (60 males and 55 females). The levels of serum OC and energy metabolism indicators were measured with electrochemiluminescence and end point methods. The relationship between serum OC and TC, TG, DL-C, LDL-C, FINS, FPG, and HOMA-IR was analyzed. Results OC levels between men and postmenopausal women were statistically significant (P<0.05). In correlation analysis, there was a significant negative correlation between age and serum OC in both males and females (Rmale =–0.517, Rfemale =–0.568). There was a significant negative correlation between BMI and serum OC in both males and females (Rmale = –0.286, Rfemale =–0.453). There was a significant positive correlation between HDL-C and serum OC in male subjects (RHDL-C=0.271). There was a significant negative correlation between TG and serum OC (RTG = –0.34), and a significant positive correlation between HDL-C and serum OC (RHDL-C=0.275), in female subjects. There was a significant negative correlation between FINS, HOMA-IR, and serum OC in male subjects (RFINS =–0.295, RHOMA-IR =–0.28). There was no significant correlation among FPG, FINS, HOMA-IR, and serum OC in female subjects. Conclusion Among the selected subjects, serum levels of OC in postmenopausal women are significantly lower than those in premenopausal women. Obesity is more pronounced in postmenopausal women. Age and BMI are significantly and negatively correlated with serum OC, indicating that serum OC may cause obesity. Serum OC is associated with body energy metabolism. |