| Objective To investigate if plasma gelsolin (GSN) protein level is associated with hip bone mineral density (BMD) in Chinese population. Methods The study group (group A) consisting of patients (>55 years old) in our hospital was divided into osteoporosis group (OP group, BMD T score ≤–2.5) and normal BMD (NBMD group, BMD T score ≥–1 at all sites). The female patients were divided to group B (less than 70 years old) and group C (older than 70 years old). Serum GSN levels were measured. Results In group A, no difference in serum GSN concentrations was observed among the total subjects (P = 0.116) and between men and women (P = 0.977). Pearson correlation analysis showed a negative correlation between serum GSN and BMD in group B and group C (r =–0.19, P = 0.081). BMD was significantly associated with PINP (r=–0.35, P = 0.002), age (r=–0.38, P<0.001), and BMI (r = 0.70, P < 0.001). There was a significant negative correlation between GSN and BMD (r =–0.26, P = 0.033). Conclusion Serum GSN is associated with hip BMD in Chinese postmenopausal women. Serum GSN might be a potential biomarker for osteoporosis risk. |