| Objective To explore the FRAX in the evaluation of 10-year fracture risk in PMOF, in the elderly with different age, sex, body mass index, bone mineral density (BMD), and bone metabolic related index 25(OH)D3, PTH, and N-MID, in the southern suburb of Beijing, and to study the correlation between PMOF, bone mineral density, and bone metabolism-related biochemical markers. Methods A total of 1083 patients who underwent distal bone mineral density (BMD) examination with DXA were enrolled. The FRAX fracture risk assessment tool was used to calculate the main body fracture probability (PMOF). The corresponding biochemical indicators of bone metabolism were collected, including 25-hydroxyvitamin D3 [25 (OH)D3], serum osteocalcin N-terminal molecular fragment (N-MID), parathyroid hormone (PTH), serum calcium (Ca) and phosphorus (P), and serum alkaline phosphatase (ALP). The change trend of each index with age and the gender difference among different age groups were analyzed and compared. Multiple stepwise regression method was used to analyze the relationship between fracture risk probability (PMOF), BMD and various biochemical indicators in the next 10 years. Results BMD of the distal radius of non-dominant arm decreased following aging. The mean BMD was higher in males than in females in each age group. PMOF increased following aging, and it was lower in males than in females in each age group, with significant difference (P<0.05). The levels of 25 (OH)D3 were higher in males than in females in each age group. N-MID was lower in males than in females in over 50 years old groups. Multiple stepwise regression analysis showed that BMD was negatively correlated with age and N-MID, but was positively correlated with BMI. PMOF was negatively correlated with BMD and age, but was positively correlated with BMI and N-MID. PMOF was the lowest in the normal BMI groups, but was the highest overweight groups, among different gender and age groups, with significant difference. The correlations between other biochemical indexes and BMD, PMOF were not significant. Conclusion BMD and PMOF are associated with gender, age, BMI, and osteocalcin. The risk of female OF is higher than that of male OF. BMD decreases with aging and the risk of fracture increases. BMD is positively correlated with BMI, but PMOF shows that fracture risk is high in overweight people. Therefore, overweight is a risk factor for fractures. With the increase of serum osteocalcin, BMD is reduced, and the risk of fracture is increased, which reflects the bone metabolism to some extent. Paying attention to the changes of biochemical indicators of bone metabolism can predict BMD and PMOF level to a certain extent, and provide evidence and theoretical basis for early detection, early diagnosis, early prevention, and early treatment of osteoporosis and fractures. |