| Objective To study the relationship between serum osteoprotegerin and the change of bone mineral density (BMD) in patients with different glucose tolerance. Methods Two hundred and seventy-one unrelated postmenopausal women were recruited in community from January to December 2013. All subjects were divided into 3 groups, according to different glucose tolerance levels. There were 93 cases in type 2 diabetes group, 90 in impaired glucose regulation group, and 88 in normal glucose regulation group. Height, weight, hip circumference, and waist circumference of the subjects were measured. Biochemical indicators were evaluated with an automatic biochemical analyzer. Serum concentrations of OPG were measured using enzyme-linked immunoassay method. BMD was examined using dual energy X-ray absorptiometry. Results BMD of the femoral neck and lumbar spine in type 2 diabetes group was higher than in NGT group (P=0.004, P=0.008). Age, high density lipoprotein, serum creatinine, alkaline phosphatase, and serum concentrations of OPG were negatively correlated with BMD of the femoral neck and lumbar (P<0.05). Height, weight, body mass index, hip circumference, waist circumference, and blood uric acid were positively correlated with BMD of the lumbar spine and femoral neck (P<0.05). Multiple regression analysis showed that age, BMI, body fat content, blood uric acid, alkaline phosphatase, and serum creatinine were associated with lumbar BMD (P<0.05). Age, BMI, serum uric acid, and alkaline phosphatase were associated with femoral neck BMD (P<0.05). Conclusion BMD in patients with different glucose tolerance is different and is influenced by many factors. The level of serum OPG may be related to the change of BMD in diabetic patients. |