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| 早期使用双膦酸盐预防糖尿病性骨质疏松的研究 |
| Research of bisphosphonate on the early prevention and treatment of diabetic osteoporosis |
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| DOI：10.3969/j.issn.1006.7108.2019.11.020 |
| 中文关键词: 2型糖尿病 双膦酸盐 骨质疏松 |
| 英文关键词:type-2 diabetes mellitus bisphosphonate osteoporosis |
| 基金项目:广东省江门市科技局课题（2018C033） |
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| 中文摘要: |
| 目的 对51例病史长短不一且合并骨量低下或已发生骨质疏松的2型糖尿病患者使用双膦酸盐静脉注射，并对注射双膦酸盐前后所测得骨密度的数据结果进行统计学分析，评价其疗效与病史长短之间的关系。方法 （1）选择标本并分组：选择51例病史长短不一且合并骨量低下或已发生骨质疏松的2型糖尿病患者，且保证其年龄、性别控制在50～80岁男性，或小于80岁的绝经女性，按照其糖尿病病史分为3组：A组（1～5年组），B组（6～10年组），C组（＞10年组）；（2）利用双能X线骨密度仪检测各个患者注射唑来膦酸钠前后的Ward’s三角以及L1-L3椎体的骨密度；（3）运用方差分析方法分析糖尿病病史长短对双膦酸盐防治骨质疏松疗效的影响。结果 6～10年组与＞10年组之间的防治骨质疏松疗效差异无统计学意义；1～5年组防治骨质疏松疗效优于6～10年组以及＞10年组。结论 早期使用双膦酸盐静脉注射进行预防糖尿病性骨质疏松可取得更好疗效。 |
| 英文摘要: |
| Objective In 51 cases of type-2 diabetic patients of different diabetic duration with osteopenia or osteoporosis, bisphosphonate injection was given and each patient’s bone mineral density before and after the injection of diphosphonate was measured, and the data was analyzed by statistical method to evaluate the relationship between the curative effect of bisphosphonate and the length of patients’ diabetic duration. Methods (1) Subjects were selected and divided into groups: 51 cases of type-2 diabetic patients with varied diabetic duration with osteopenia or osteoporosis were selected; male patients aged 50-80 years while female patients aged under 80 years and were postmenopausal. Patients selected were divided into 3 groups according to their diabetic duration: Group A: 1-5 years group, Group B: 6-10 years group, Group C: above 10 years group; (2) Each patients’ bone mineral density at ward’s triangle and 1-3 lumbar vertebral body before and after the injection of diphosphonate was measured by dual energy X-ray bone densitometer. Analysis of variance was used to estimate how the length of diabetic duration affects the curative effect of diphosphonate. Results The 6-10-years duration group had no significant statistical difference compared with the above-10-years group. The 1-5-years duration group had a better curative effect than the 6-10-years group and the above-10-years group. Conclusion Use diphosphonate to treat and prevent diabetic osteoporosis in the early phase could get a better curative effect. |
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