| The change of intestinal flora has many influences on the host. The changes of intestinal structure and physiological function caused by metabolic surgery affect the microflora living in the intestinal tract. The changes are involved in postoperative weight loss, glucose metabolism, and lipid metabolism. At the same time, many studies have confirmed that the changes of intestinal flora have a significant impact on the bone metabolism by affecting the host's metabolic system, nervous system, and immune regulatory system. Probiotics, as an active microorganism which is beneficial to the host, have attracted more and more attention for their effect on bone protection. This article reviews the change of intestinal flora after metabolic surgery and the effect of intestinal flora and probiotics on the bone metabolism, summarizes the recent research progress and hot spots, and bridges research between postoperative intestinal flora and metabolic bone metabolism, in order to provide basis for the flora treatment and target research after metabolic surgery. |