| Objective To explore the regularity of annual changes of bone mineral density (BMD) in postmenopausal women during follow-up. Methods Questionnaire survey and follow-up were performed in postmenopausal women in Fuzhou. BMD of the lumbar vertebrae, left femoral neck, and left greater trochanter was measured using dual energy X-ray absorptiometry. The annual changes in BMD were analyzed according to the treatment with or without calcium tablets and follow-up time, etc. Results A total of 206 participants were followed up. The average age was 61.35 ?5.50 years old. During the follow-up period, the incidence of fracture was 7.69% in the intervention group and 16.00% in the non-intervention group. The annual changes of BMD of the lumbar spine, femoral neck and trochanter in intervention group were 0.0205 g/cm2, -0.0298 g/cm2, and -0.0272 g/cm2. The annual changes of BMD of the lumbar spine, femoral neck and trochanter in non-intervention group were 0.0067 g/cm2, -0.0219 g/cm2, -0.0169 g/cm2. BMD of the lumbar spine increased in intervening group during the follow-up. In the non-intervening group, it increased in the first three years of follow-up, and then decreased. BMD of the greater trochanter decreased faster than that of the femoral neck in the intervention group during the follow-up period. In the non-intervention group, BMD of the greater trochanter decreased faster in the first three years of follow-up, and then decreased faster in the femoral neck. Conclusion The results show that the effect of intervention is better in the lumbar BMD than that in the hip. There is difference in BMD loss in different parts of the body. The loss of BMD in the left upper femur is faster than that in the lumbar spine. With the increase of follow-up time, the changes of BMD in different parts tend to be stable. |