| Objective To investigate the clinical significance of detection of bone mineral density (BMD) and bone turnover markers (BTMs) in the elder women with osteoporosis, and to compare their predictive power of osteoporotic fracture (OF). Methods From October 2017 to February 2019, 96 patients with OF and 107 patients with osteoporosis who were hospitalized in the department of orthopedics at the First Affiliated Hospital of Chengdu Medical College were examined. They were divided into fracture group and non-fracture group. BMD was measured using dual-energy X-ray absorptiometry (DXA). BTMs, including type I procollagen amino terminal peptide (PINP), β-cross-linked C-telopeptide of type I collagen (β-CTX), and molecular fragment of osteocalcin N terminal (N-MID) were detected with electrochemiluminescence. Bone metabolism related indicators, including alkaline phosphatase (ALP), calcium (Ca), and phosphorus (P) were detected at the same time. The measurement data between the two groups were compared using independent-samples t test. The correlation between BMD and BTMs and OF was analyzed using binary logistic regression. Results BMD in the fracture group was lower than that in the non-fracture group (P<0.05). PINP and β-CTX were higher than in the non-fracture group. N-MID was lower than in the non-fracture group in 70 - 90 years old patient, and the difference was statistically significant(P<0.05). There was no significant difference in ALP, P, and Ca between two groups (P>0.05). Binary logistic regression analysis showed that BMD in the lumbar spine and hip was significantly correlated with β-CTX and OF (OR=-4.182, -6.929, 7.572, respectively), and the differences were statistically significant (P<0.05). PINP and N-MID were positively correlated with OF (OR=4.213, 2.510, respectively), but the difference was not statistically significant (P>0.05). Conclusion Osteoporotic elder women with low BMD and high β-CTX are more likely to develop OF. β-CTX is more capable than BMD to predict OF. It can help timely manage and take related interventions for the high-risk population. |