| Objective To evaluate the clinical efficacy of Jintiange Capsule in the treatment of Osteoporosis (OP). Methods Cochrane Library, Springer Link, EMBASE, PubMed, China Biomedical Literature Database (CBM), Wanfang Database, China Knowledge Network Database (CNKI), and VIP Chinese Journal Database (VIP) were searched from the construction of the database to September 2018. Some related journals were manually retrieved. Randomized controlled trials concerning Jintiange capsule for the treatment of OP were collected. Qualified articles were screened and the quality of the included literature was assessed using the Cochrane Risk Bias Evaluation Tool and the Jadad Scale. Meta analysis was performed using RevMan 5.3 software provided by the Cochrane Collaboration. Results A total of 161 articles were retrieved, and 15 randomized controlled studies were included in the screening. A total of 1957 patients were involved. The quality of the included literatures was low. Only 3 papers were grouped by random number table using computer randomization. There was 1 paper grouped, and 1 document described the results of safety evaluation. All the literatures included did not explain the hidden methods of randomized allocation, case shedding, or whether blind method, sample size estimation method and follow-up were used. The Jadad score was ≤ 2 points. All the 15 literatures were compared with the clinical efficacy between the intervention group and the control group. The results were homogeneous (I2=0%，P=0.88). The effective rate in the treatment group was higher than that in the control group [Z=9.64, P<0.01; OR=4.61, 95% CI (3.38, 6.30)]. The funnel plot showed that the experimental studies were distributed on both sides of the vertical line, the distribution was relatively uniform, and there was no publication bias. Conclusion Jintiange capsule alone or in combination with other therapies can effectively alleviate the clinical symptoms of OP patients. Due to the limitations of the quality of the study and the number of cases included in this study, the above conclusions require further high-quality randomized controlled trials to further validate. |