| Objective To explore the correlation between serum uric acid and bone mineral density (BMD) and bone turnover markers in patients with type 2 diabetes mellitus. Methods A total of 323 patients with type 2 diabetes were the study subjects. The levels of serum uric acid(UA), fasting blood glucose (FPG), glycosylated hemoglobin (HbAlc), homocysteine (Hcy), Ca2+, P, Mg, alkaline phosphatase(ALP), β-caroxyl terminal peptide(β-CTX), type I procollagen N-terminal proeptide (PINP), parathyroid hormone (PTH), 25(OH)D, and osteocalcin (OC) were examined. BMD of the lumbar spine L1-L4 was detected. The differences among various indicators at different uric acid and BMD levels were compared. The relationship between the indicators was further clarified using Pearson correlation analysis, multiple linear regression analysis, or ROC work curve. Results The T-value in the high uric acid group was higher than that in the low uric acid group (in males, -0.26±0.52 vs -2.01±0.40; in females, 0.29±0.67 vs -2.38±0.37, P<0.05). The UA level in the normal bone mass group was higher than that in the osteoporosis group (in males, 353.57±91.07 vs 289.49±72.8; in females, 372.41±113.26 vs 293.50±53.84, P<0.05). Uric acid was positively correlated with BMD (in males, r=0.283; in females, r=0.211, P<0.05). Uric acid was positively correlated with 25(OH)D, PTH, and OC, but not with other indicators. In multiple linear regression analysis, uric acid was still positively correlated with BMD of the lumbar vertebrae after controlling multiple variables affecting BMD. The maximum corresponding uric acid level Youden index was 345 μmol/L in males and 315 μmol/L in females, respectively. Conclusion The serum level of uric acid is positively correlated with BMD of the lumbar vertebrae in patients with type 2 diabetes. |