男性骨质疏松症药物治疗现状与展望
Drug therapy for osteoporosis in men: current situation and perspective
  
DOI:10.3969/j.issn.1006-7108.2020.01.028
中文关键词:  骨质疏松  药物治疗  男性
英文关键词:osteoporosis  drug therapy  male
基金项目:
作者单位
李辉 刘焕兵* 南昌大学第一附属医院江西 南昌 330006 
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中文摘要:
      随着我国人口老龄化程度的加剧,老年人口不断增多,骨质疏松(osteoporosis,OP)将成为严峻的公共卫生问题。与此同时,男性OP的发病率逐渐上升,却一直未受到应有的关注。目前可用于男性OP治疗的药物有维生素D与钙剂、双膦酸盐、锶盐、甲状旁腺素制剂、核因子-κB受体配体(nuclear factor-κB receptor ligand,RANKL)活化剂、骨硬化蛋白单克隆抗体、选择性雌激素调节剂(selective estrogen receptor modulator,SERMs)等。另有许多新药处于研发或临床试验阶段,有望进一步改善男性骨质疏松治疗效果,提高生活质量。笔者将简要介绍男性OP治疗药物的种类及作用机理,以提高认识。
英文摘要:
      Following the population aging in our country, the elderly population is increasing. Osteoporosis becomes a serious public health and social problem. At the same time, the incidence of male osteoporosis has gradually increased. However, it has not been paid serious attention. Currently, drugs available for male osteoporosis include bisphosphate, parathyroid hormone analogues, nuclear factor-κB receptor ligand (RANKL) activators, sclerostin monoclonal antibody, and selective estrogen receptor modulator (SERMs), etc. Many other new drugs are in clinical trials or in research and development, which are expected to further improve the treatment of male osteoporosis and improve the quality of life. This article briefly describes the types of drugs for male osteoporosis treatment and the mechanism of action of the drugs to improve understanding.
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