| With the development of society, the prevalence of chronic kidney disease is on the rise, and the base of patient population has been expanding. As one of the main complications of chronic kidney disease, renal osteodystrophy is prone to osteoporosis and fracture, which seriously affects the prognosis of patients. In recent years, with the increasing attention to renal osteopathy and the deepening of research, relevant scholars have further studied the mechanism of renal-PTH signaling pathway in renal osteopathy. It has been found that other important molecular signaling pathways are involved in the regulation of the progression of renal osteopathy. Researches show that the pathogenesis of renal osteodystrophy is referred to a network of signaling pathways, in which the renal-PTH pathway plays the central role. The balance of bone formation and resorption is regulated through the Wnt/β-catenin pathway and the BMP pathway. Klotho gene and bone FGF23 molecule help to balance and to feedback. Therefore, it is necessary to conduct research on related medicine and to improve the prognosis by regulating the molecular signaling pathway related axis. Meanwhile, bone diseases as a late clinical syndrome of chronic kidney disease should be taken care, in order to establish a more effective treatment. This article reviews the abovementioned research progress on the signaling pathway of renal osteopathy and provides a reference for further investigation of the pathogenesis of renal osteodystrophy for the prevention and treatment. |