|
| 中老年女性乳腺癌患者骨丢失的临床研究 |
| Clinical study of bone loss in middle-aged and older women with breast cancer |
| |
| DOI：10.3969/j.issn.1006-7108.2020.02.025 |
| 中文关键词: 乳腺癌 骨密度 骨质疏松 女性 中老年 |
| 英文关键词:breast cancer bone mineral density osteoporosis women middle-aged and elderly |
| 基金项目: |
|
| 摘要点击次数: 839 |
| 全文下载次数: 385 |
| 中文摘要: |
| 目的 观察中老年女性乳腺癌患者骨密度（bone mineral density,BMD）变化及影响因素。方法 选取40岁以上乳腺癌患者339例为乳腺癌组，同时选择1 356名健康女性为对照组。通过美国GE LUNAR公司生产的Prodigy advance双能X线骨密度仪测量受试者腰椎（L1~4）、左股骨BMD。对比乳腺癌组、对照组BMD及骨质疏松(osteoporosis,OP)患病率。结果 ①随着增龄，乳腺癌与对照组腰椎、股骨BMD逐渐降低。乳腺癌组腰椎、左侧股骨干、全髋BMD 40~49岁年龄段低于对照组，50~80岁年龄段高于对照组。乳腺癌组左侧股骨颈、大转子BMD 40~59岁年龄段低于对照组，60~80岁年龄段高于对照组;②体质量指数（bone mass index, BMI）与腰椎、股骨BMD呈正相关（r=0.101~0.283, P＜0.01）。亚洲骨质疏松自我评价工具(osteoporosis self-assessment Tool for Asians，OSTA)与BMD呈正相关（r=0.382~0.592, P＜0.01）;③随着增龄，乳腺癌与对照组OP检出率逐渐增加。对照组腰椎OP检出率高于乳腺癌组。50~80岁年龄段股骨OP检出率高于乳腺癌组。结论 中老年女性乳腺癌患者与健康人群均有较高骨丢失率。50岁以后健康人群OP患病率高于乳腺癌患者。OSTA对乳腺癌OP风险有较好预测价值。 |
| 英文摘要: |
| Objective To investigate changes in bone mineral density (BMD) and associated factors in middle-aged and older women with breast cancer. Methods A total of 339 patients aged over 40 years with breast cancer were selected as study group, and 1356 healthy women were selected as control group. Bone mineral density (BMD) of lumbar spine (L1-4) and left femur was measured using GE Lunar Prodigy advance. BMD measures and the prevalence of OP in different age groups of breast cancer group (BCG) and control group (CG) were compared. Results ①BMD of L1-4 and femur decreased in both CG and BCG with aging. BMD of L1-4, femoral shaft and total left femur in 40-49 years old in BCG was lower than that in CG, while in 50-80 years old was higher than that in CG. BMD of femoral neck and trochanter in 40-59 years old in BCG was lower than that in CG, while in 60-80 years old was higher than that in CG;②Body mass index (BMI) was positively correlated with BMD (r=0.101-0.283, P<0.01). Osteoporosis self-assessment Tool for Asians (OSTA) was positively correlated with BMD measures (r=0.382-0.592, P<0.01);③The rate of OP detection in BCG and CG increased gradually with aging. Prevalence of L1-4 OP in 40-80 years old and femur OP in 50-80 years old in CG was higher than that in BCG. Conclusion There was a high incidence of bone loss in middle-aged and older women with breast cancer and healthy people. The prevalence of OP in healthy population was higher than that in breast cancer patients aged over 50 years. OSTA was valuable in predicting the risk of OP in women with breast cancer. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |