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| 从生物力学角度探讨酒精对大鼠股骨干及股骨头影响的实验研究 |
| Experimental study on the effect of alcohol on the femoral shaft and femoral head in rats from the perspective of biomechanics |
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| DOI：10.3969/j.issn.1006.7108.2020.03.001 |
| 中文关键词: 生物力学 酒精 骨折 股骨干 股骨头 |
| 英文关键词:biomechanics alcohol fracture femoral shaft femoral head |
| 基金项目:国家自然科学基金项目（81774343）；黑龙江省中医药科研项目（ZHY18-066）；黑龙江中医药大学科研基金项目（201811）；哈尔滨市应用技术研究与开发项目（2017RAXXJ047） |
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| 中文摘要: |
| 目的 探究长期酒精灌胃对大鼠股骨干及股骨头生物力学的影响。方法 35只SD大鼠随机分组，其中酒精组20只给予46%酒精每周灌胃4次，空白组15只，灌胃等体积生理盐水。4个月后取双侧股骨干行三点弯曲试验，双侧股骨头行压缩试验，SPSS 23.0软件进行统计分析。结果 与空白组相比，酒精组股骨干弹性模量、刚度系数、最大载荷、破坏载荷等力学参数均降低，而韧性系数、弹性应变、最大应变、弹性挠度和最大挠度不同程度地增加，差异均有统计学意义 (P<0.05)；酒精组大鼠股骨头弹性载荷和最大载荷均降低，差异均有统计学意义 (P<0.05)。结论 长期酒精摄入可降低大鼠股骨干及股骨头抵抗外力的生物力学性能，使骨折风险增加。 |
| 英文摘要: |
| Objective To explore the effect of long-term alcoholic gavage on the biomechanics of femoral shaft and femoral head in rats. Methods Thirty-five Sprague-Dawley rats were randomly divided into groups. Among them, 20 rats in the alcohol group received 46% alcohol for four times a week, and 15 rats in the blank group received an equal volume of normal saline. Four months later, the bilateral femoral head was subjected to a three-point bending test, and the bilateral femoral head was compressed. SPSS 23.0 software was used for statistical analysis. Results Compared with the blank group, the elastic parameters such as elastic modulus, stiffness coefficient, maximum load, and failure load of the femoral shaft in the alcohol group decreased, while the toughness coefficient, elastic strain, maximum strain, elastic deflection, and maximum deflection increased to varying degrees. All the differences were statistically significant (P<0.05). The elastic load and maximum load of the femoral head in the alcohol group decreased, and the differences were statistically significant (P<0.05). Conclusion Long-term alcohol intake reduces the biomechanical properties of the femoral shaft and femoral head in rats against external forces, which increases the risk of fracture. |
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