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| WISP1、sFRP5与2型糖尿病患者骨转换指标及骨密度相关性分析 |
| Correlation between adipokines WISP1 and sFRP5 and bone turnover markers and bone mineral density in patients with type 2 diabetes mellitus |
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| DOI：10.3969/j.issn.1006.7108.2020.03.011 |
| 中文关键词: 2型糖尿病 骨质疏松症 骨转换指标 WISP1 sFRP5 |
| 英文关键词:type 2 diabetes mellitus, osteoporosis, bone turnover markers, WISP1, sFRP5 |
| 基金项目:桂林市科学研究与科技开发计划课题（20180106-4-5）；广西壮族自治区卫生和计划生育委员会自筹经费科研课题（Z2016387） |
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| 中文摘要: |
| 目的 探讨脂肪因子WISP1、sFRP5与2型糖尿病（T2DM）患者骨转换指标及骨密度（BMD）的相关性。方法 选取125名2017年5月至2018年12月在本院老年内科住院且初诊为T2DM患者，年龄在50~80岁。采用双能X线吸收检测法（DXA）对以上受检者进行腰椎及髋部BMD测定，以最低T值作为分组依据，将受检者分为：T2DM并骨量正常组（n=42例）；T2DM并骨量减少组（n=43例），T2DM并骨质疏松症组（n=40例）。详细记录受检者的性别、年龄、糖尿病病程、身高和体重等相关资料，计算体质指数（BMI），并测定HbA1c、FPG、N-MID、P1NP、β-CTX指标，通过酶联免疫吸附方法（ELISA）测定血清WNT1诱导型信号传导途径蛋白1（WISP1）、分泌型卷曲相关蛋白5（sFRP5）水平。结果 ①三组间血清sFRP5比较，骨质疏松症组和骨量减少组均高于骨量正常组（P＜0.05），且sFRP5与BMD呈负相关（r=–0.417，P＜0.05）；②三组间WISP1相互比较，骨质疏松症组和骨量减少组均比骨量正常组都要低（P＜0.05），且WISP1与BMD呈正相关（r=0.22，P＜0.05）。结论 血清脂肪因子sFRP5、WISP1水平的变化与T2DM患者BMD有一定的相关性。 |
| 英文摘要: |
| Objective To investigate the correlation between adipokines WISP1, sFRP5 and bone turnover markers and bone mineral density (BMD) in patients with type 2 diabetes mellitus (T2DM). Methods According to the exclusion criteria, 125 newly diagnosed T2DM patients who were hospitalized in our hospital from May 2017 to December 2018 and aged between 50 and 80 years old were selected. BMD of the lumbar spine and hip of the subjects was detected using dual energy X absorptiometry (DXA). The lowest T value was used for grouping. The subjects were divided into: T2DM and normal bone mass group (n = 42 cases), T2DM and osteopenia group (n = 43 cases), T2DM and osteoporosis group (n = 40 cases). Gender, age, duration of diabetes, height, and weight of the subject were recorded. Body mass index (BMI) was calculation. HbA1c, FPG, N-MID, P1NP, and β-CTX were determined. Serum levels of WNT1 inducible signaling pathway protein 1 (WISP1) and secreted frizzled-related protein 5 (sFRP5) were determined using enzyme-linked immunosorbent assay (ELISA). Results 1) Serum level of sFRP5 in the osteoporosis group and the osteopenia group was higher than that in the normal bone group (P<0.05), and sFRP5 was negatively correlated with BMD (r=–0.417, P<0.05). 2) WISP1 level was lower in the osteoporosis group and osteopenia group than in the normal bone mass group (P<0.05), and WISP1 was positively correlated with BMD (r=0.22, P<0.05). Conclusion The changes of serum adipokines sFRP5 and WISP1 levels have a certain correlation with BMD in patients with T2DM. |
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