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| 健康中年人血清炎症标志物与骨密度的相关性研究 |
| Correlation between serum inflammation markers and bone mineral density in healthy middle-aged adults |
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| DOI：10.3969/j.issn.1006.7108.2020.03.015 |
| 中文关键词: 脂联素 骨密度 C反应蛋白(CRP) 脂联素 肿瘤坏死因子-α(TNF-α) |
| 英文关键词:adiponectin, bone mineral density, C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) |
| 基金项目: |
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| 摘要点击次数: 602 |
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| 中文摘要: |
| 目的 探讨健康中年人血清C反应蛋白(CRP、脂联素、肿瘤坏死因子-α(TNF-α)与骨密度之间相关性。方法 我们测量了76名成人的血清CRP、脂联素、TNF-α以及腰椎和股骨颈骨密度(BMD)并分析之间相关性。结果 按照BMD检测结果将76名参与者分为两组： BMD正常组(40，52.6%)，和BMD降低组(36，47.4%)。BMD降低组CRP较BMD正常组水平显著升高，差异有统计学差异(P＜0.05)。 BMD降低组的脂联素水平较低，但差异无统计学意义(P＞0.05)。BMD降低组的TNF-α水平较高，差异无统计学意义(P＞0.05)。Pearson相关系数分析显示BMD降低组的BMD与CRP呈负相关性。结论 健康中年人血清CRP与BMD呈负相关性。 |
| 英文摘要: |
| Objective The aim of this study was to investigate the correlation among serum C-reactive protein (CRP), adiponectin, tumor necrosis factor-α (TNF-α), and bone mineral density (BMD) in healthy middle-aged people. Methods Serum levels of CRP, adiponectin, TNF-α, and BMD of the lumbar spine and femoral neck were measured in 76 adults. Results 76 participants were divided into two groups according to BMD results: BMD normal group (n=40, 52.6%) and BMD reduction group (n=36, 47.4%). CRP in the BMD reduction group was significantly higher than that in the normal BMD group, and the difference was statistically significant (P<0.05). The adiponectin concentration in the BMD reduction group was lower, but the difference was not significant (P>0.05). The concentration of TNF-α in the BMD reduction group was higher, but the difference was not statistically significant (P>0.05). Pearson coefficient correlation analysis showed that BMD in the BMD reduction group was negatively correlated with CRP. Conclusion Serum CRP is negatively correlated with lower BMD in healthy middle-aged people. |
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