| Objective To explore the effect of 3-year perindopril treatment on bone mineral density (BMD) and bone metabolism in middle-aged and elderly patients with hypertension. Methods One hundred and thirty-eight patients with hypertension and osteoporosis were randomly divided into treatment group (n = 69) and control group (n = 69). Patients in the treatment group received perindopril and in the control group received levofloxacin benzenesulfonate, respectively. Treatment lasted for 36 months. The levels of serum type I collagen cross-linked C-terminal peptide (CTX), tartrate Acid Phosphatase (TRAP), bone specificity of alkaline phosphatase (BALP), and BMD of the lumbar L1-4 and femur trochanter, left femoral neck, and Ward’s triangle were measured before and 36 months after the treatment. Results After 36-month treatment, the levels of BLAP and BMD of the lumbar L1-4 and femur trochanter, left femoral neck, Ward’s triangle increased significantly, but the levels of CTX and TRAP decreased significantly (P<0.05). After the treatment, BLAP, CTX, and TRAP, and BMD of the lumbar L1-4 and femur trochanter, left femoral neck, Ward’s triangle were significantly better in the treatment group than those in the control group (P<0.05). Conclusion Long-term perindopril treatment has a certain effect on BMD and bone metabolism in patients with hypertension and osteoporosis. |