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| 阿仑膦酸钠联合独活寄生汤对骨质疏松患者的临床应用效果及患者骨代谢生化指标变化情况分析 |
| Clinical effect of alendronate sodium combined with angelica pubescens and parasitism decoction on osteoporosis and biochemical indexes of bone metabolism |
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| DOI：10.3969/j.issn.1006.7108.2020.03.026 |
| 中文关键词: 阿仑膦酸钠 独活寄生汤 骨质疏松 骨代谢 生化指标 |
| 英文关键词:alendronate sodium angelica pubescens and parasitism decoction osteoporosis bone metabolism biochemical indicators |
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| 中文摘要: |
| 目的 分析阿仑膦酸钠联合独活寄生汤对骨质疏松患者的临床应用效果及患者骨代谢生化指标变化情况。方法 将2016年10月至2018年10月期间因骨质疏松于河北省中医院进行治疗的140例患者，应用随机法将其分为2组，观察组与对照组、各70例，其中对照组单独使用阿仑膦酸钠治疗，观察组在对照组基础上加用独活寄生汤进行联合治疗。对比两组不同治疗方案下疗效及骨代谢生化指标变化情况的差异。结果 观察组总有效率95.71%高于对照组80.00%，对比差异具有统计学意义（P<0.05）；相比于治疗前，治疗后两组ALP明显升高，U-Ca明显下降（P＜0.05）；治疗后两组对比，观察组ALP明显高于对照组，U-Ca明显低于对照组（P＜0.05）；观察组不良反应4.29%低于对照组15.71%，差异有统计学意义（P<0.05）。结论 针对骨质疏松患者临床治疗时，阿仑膦酸钠联合独活寄生汤的使用可有效改善患者多项临床症状，提高治疗有效率，同时改善骨代谢情况，临床推广应用价值显著。 |
| 英文摘要: |
| Objective To analyze the clinical effect of alendronate sodium combined with angelica pubescens and parasitism decoction on osteoporosis and the changes of biochemical indexes of bone metabolism. Methods One hundred and forty patients with osteoporosis treated in our hospital from October 2016 to October 2018 were selected as the study subjects. The patients were divided into observation group and control group by random number table method. The patients in the control group received alendronate alone, while the patients in the observation group received angelica pubescens and parasitism decoction in addition to alendronate. The difference of curative effect and biochemical indexes of bone metabolism between the two groups under different treatment schemes was compared. Results The total effective rate in the observation group (95.71%) was significantly higher than in the control group (80.00%, P < 0.05). Compared to those before the treatment, ALP level increased and U-Ca level decreased in both groups after the treatment. ALP level in the observation group was higher, and U-Ca was lower, than in the control group after the treatment (P < 0.05). The incidence of adverse reaction in the observation group (4.29%) was significantly lower than that in the control group (15.71%) after the treatment (P < 0.05). Conclusion In the clinical treatment of osteoporosis, alendronate sodium combined with angelica pubescens and parasitism decoction effectively relieves many clinical symptoms, improves the treatment efficacy, and relieves bone metabolism. It has significant clinical application value. |
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