| The incidence of osteoporosis (OP) is increasing year by year, seriously affecting the live of the patients. TCM treatment of OP has advantages, but its development is limited by the lack of objectivity, standardization, and modernization of TCM syndrome differentiation. This review analyses and evaluates the current research status of TCM syndrome modernization of OP. By screening the literatures from Chinese and English databases, it is found that the differentiation of TCM syndrome type of OP is not uniform. The commonly used OP modernization indicators can not fully elaborate the essence of "syndrome". Therefore, it is proposed that universally recognized TCM syndromes are the basis of scientific research. New technologies such as LncRNA, microRNA, and genomics in non-coding RNA can provide new ideas and more comprehensive scientific basis for TCM syndrome research of OP. It is the further study direction by combination of OP TCM syndromes with genomics technology, by application of the genomics technology to detect the efficacy of TCM in treating OP of different TCM syndromes, and by the correlation between kidney deficiency syndrome of OP and LncRNA, microRNA, target gene reticular regulatory system. |