| Angiogenesis and osteogenesis are essential parts of bone development. The regeneration and angiogenic–osteogenic coupling exist through the whole process of bone formation and remodeling, which play important roles in the mechanisms such as new bone formation, fracture healing, bone defect repair, and osteoporosis. Vascular endothelial cells, vascular endothelial growth factors, and other factors are key parts in angiogenic–osteogenic coupling. Especially in recent years, the discovery of specific H-type blood vessel enriches the content of vascular-osteogenesis coupling and deepens the understanding of the coupling. Blood vessels and bones are closely related and interacted with each other. The significances of blood vessels to bones are not only the transmission of bone-transferring substances, but also the secretion of factors, signal transmission, function regulation, and so on. Bone related cells can secrete or promote the secretion of vascular endothelial growth factor and other angiogenic factors, which regulate angiogenesis. Therefore, this present paper summarizes the role of angiogenic–osteogenic coupling-related factors, cells, and their mechanisms in the bone. |