| Objective To screen the target and signaling pathway of the effective ingredients of Rhizoma Drynariae in the treatment of osteoporosis by network pharmacology. Methods Firstly, TCMSP analysis platform, GeneCards database and OMIM database were used to screen the active ingredients and corresponding targets of Traditional Chinese Medicine (TCM), and the common target of TCM-Disease was obtained by intersecting the target of TCM with the target of disease, and the regulatory network of TCM-Disease-Target was constructed. Then, the core target genes were screened by constructing the protein protein interaction (PPI) network of common target of TCM-Disease. Finally, GO function enrichment analysis and KEGG function enrichment analysis were carried out on the common target of TCM-Disease, and the signal pathways related to the common target of TCM-Disease were obtained. Results 18 effective ingredients and 98 common targets of TCM-Disease were screened for the treatment of osteoporosis. The mechanism of action may be related to AGE-RAGE signaling pathway, TNF signaling pathway, IL-17 signaling pathway, HIF-1 signaling pathway, Th17 cell differentiation signaling pathway, and interleukin-6 gene, JUN gene, mitogen-activated protein kinase-1 (MAPK-1) gene and epidermal growth factor (EGF) gene may play a key role. Conclusion Based on network pharmacology, the target and signal pathway of Rhizoma Drynariae in the treatment of osteoporosis were explored, which provides ideas for the modernization of TCM. |